From: Trinity College Dublin
Published February 16, 2017 01:00 PM

How cancers trick the immune system into helping rather than harming them

Scientists at Trinity College Dublin have discovered how certain cancers hijack the immune system for their benefit -- tricking it into helping rather than harming them.

While most of us are aware that our immune system protects us from infection, we may be less aware of the key role that cells of the immune system also play in coordinating the repair of damaged tissue. This 'wound-healing' aspect of the immune response stimulates growth of new cells within damaged tissue and brings extra nutrients and oxygen into the injured tissue.

However, cancers frequently exploit the wound-healing side of the immune system for their own ends. Indeed, cancers have been described as 'wounds that do not heal' due to their ability to masquerade as damaged tissue in order to receive help from the immune system. But just how cancers switch on this wound-healing response is not well understood.

Scientists from the Smurfit Institute of Genetics at Trinity College Dublin, led by Smurfit Professor of Medical Genetics, Seamus Martin, have just found that a molecule called TRAIL — which is frequently found in high concentrations on many cancers — can become 're-wired' in certain tumours to send an inflammatory 'wound-healing' signal.

Read more at Trinity College Dublin

Photo credit: Dr Conor Henry and Professor Seamus Martin, Trinity College Dublin.

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