From: Reuters
Published January 12, 2008 10:04 AM

Anxiety and depression predict events in heart patients

By Anthony J. Brown, MD

NEW YORK (Reuters Health) - New research indicates that anxiety and depression are risk factors for major heart-related events among patients with stable coronary artery disease.

"We found that both major depression and generalized anxiety disorder were more common in cardiac patients than in the general community. More importantly, both predicted about a doubling in risk for major cardiac events over two years," study chief Dr. Nancy Frasure-Smith, from the University of Montreal, told Reuters Health.

She added that her study differed from previous research in that it focused on patients with stable heart disease -- not on those who were hospitalized for a cardiac event such as heart attack.

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As reported in the Archives of General Psychiatry this month, Frasure-Smith along with Dr. Francois Lesperance, also from the University of Montreal, examined the prognostic significance of depression and anxiety in 804 patients with stable heart disease who were followed for 2 years.

Overall, 27 percent of patients showed signs of depression on a standard test and 41 percent showed signs of anxiety. Major depressive disorder was diagnosed in roughly 7 percent of patients while about 5 percent had generalized anxiety disorder.

Major depressive disorder, generalized anxiety disorder, as well as elevated scores on the depression and anxiety tests all increased the risk of a major coronary event. Of these, major depressive disorder was the strongest factor, increasing the risk by 2.85-fold. No additive effect was seen; patients with both major depressive disorder and generalized anxiety disorder had roughly the same risk of suffering a major coronary event as patients with just one of the disorders.

"Now that we know that both generalized anxiety disorder and major depression are markers of increased cardiac risk, it is imperative that these patients receive the best evidence-based treatment for both their cardiac and psychiatric conditions," Frasure-Smith emphasized.

"Extra efforts are justified in helping them change their cardiac risk factors, assure treatment compliance, and improve their emotional and social functioning," she added.

SOURCE: Archives of General Psychiatry, January 2008.

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