From: Jennifer Langston via University of Washington
Published May 25, 2017 04:21 PM

UW engineers borrow from electronics to build largest circuits to date in living eukaryotic cells

Living cells must constantly process information to keep track of the changing world around them and arrive at an appropriate response.

Through billions of years of trial and error, evolution has arrived at a mode of information processing at the cellular level. In the microchips that run our computers, information processing capabilities reduce data to unambiguous zeros and ones. In cells, it’s not that simple. DNA, proteins, lipids and sugars are arranged in complex and compartmentalized structures.

But scientists — who want to harness the potential of cells as living computers that can respond to disease, efficiently produce biofuels or develop plant-based chemicals — don’t want to wait for evolution to craft their desired cellular system.

In a new paper published May 25 in Nature Communications, a team of UW synthetic biology researchers have demonstrated a new method for digital information processing in living cells, analogous to the logic gates used in electric circuits. They built a set of synthetic genes that function in cells like NOR gates, commonly used in electronics, which each take two inputs and only pass on a positive signal if both inputs are negative. NOR gates are functionally complete, meaning one can assemble them in different arrangements to make any kind of information processing circuit.

Read more at University of Washington

Image: An artist’s impression of connected CRISPR-dCas9 NOR gates.  (Justin Vrana, University of Washington)

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