Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K pathway is common to many cancers, K-80003 could have broad therapeutic applications. Tarrex Biopharma, Inc. has licensed the compound and announced they will soon begin Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer.
>> Read the Full Article
Seasonal and diurnal rhythms determine the life cycle of many animal species. In equids this is not only true for wild species such as the Przewalski but season-dependent metabolic changes also exist in domesticated horses. Horses can reduce their metabolic activity during the cold season and thus reduce heat loss. The effects of such seasonal changes on pregnancy and foetal development, however, have not been investigated so far. Researchers from Vetmeduni Vienna could now demonstrate that foals born in winter are smaller than herd mates born later in the year.
>> Read the Full Article
The Paris Climate Agreement of 2016, which saw 195 nations come together in the shared goal of ameliorating climate change, set forth an ambitious goal of limiting global temperature rise to less than 2 degrees Celsius. Since then, many have wondered, is that even scientifically possible? Unfortunately, the odds aren’t looking good.
>> Read the Full Article
A Canadian-led investigation involving York researchers has opened a new chapter in antimatter research.
In a study published in Nature today (Aug. 3), the ALPHA Collaboration – a group of international physicists including physics Professor Scott Menary in the Faculty of Science at York University – reported the first detailed observation of spectral lines from an antimatter atom.
>> Read the Full Article
University of Lethbridge biogeography professor Dr. Dan Johnson and his team have been monitoring Prairie potato fields for the past few years, looking for evidence of the potato psyllid insect and a bacterium it can carry that can lead to zebra chip disease in potato crops.
“We found hundreds of potato psyllids last year, but we have found under 10 so far this year and none have the bacteria that cause zebra chip,” says Johnson, who coordinates the Canadian Potato Psyllid and Zebra Chip Monitoring Network.
>> Read the Full Article