New, more sensitive sensor for evaluating drug safety

A new technique for evaluating drug safety can detect stress on cells at earlier stages than conventional methods, which mostly rely on detecting cell death. The new method uses a fluorescent sensor that is turned on in a cell when misfolded proteins begin to aggregate -- an early sign of cellular stress. The method can be adapted to detect protein aggregates caused by other toxins as well as diseases such as Alzheimer’s or Parkinson’s. A paper describing the new method, by a team of researchers at Penn State University, appears in the journal Angewandte Chemie International Edition.

Carbon Conversion

Chemists have figured out a new, more efficient way to create carbon-based fuels from carbon dioxide (CO2). In chemical reactions performed in the lab, a Caltech team has identified a new additive that helps selectively convert CO2 into fuels containing multiple carbon atoms—a step toward ultimately making renewable liquid fuels that are not derived from coal or oil.

"The results were quite shocking," says Jonas Peters, Bren Professor of Chemistry at Caltech and director of the Resnick Sustainability Institute, who jointly led the research in collaboration with Theodor Agapie, professor of chemistry at Caltech. "Usually, in these types of reactions with CO2, you see a lot of by-products like methane and hydrogen. In this case, the reaction was highly selective for the more desirable fuels that contain multiple carbons—such as ethylene, ethanol, and propanol. We saw an 80 percent conversion to these multi-carbon fuel products, with only 20 percent or so going into hydrogen and methane."

NASA Spies Wind Shear Still Affecting Tropical Storm Nalgae

Tropical Storm Nalgae can’t seem to get a break from vertical wind shear. The storm has been dealing with wind shear since it formed and NASA’s Terra satellite observed that was still the case on August 4.

Drug Short-Circuits Cancer Signaling

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K pathway is common to many cancers, K-80003 could have broad therapeutic applications. Tarrex Biopharma, Inc. has licensed the compound and announced they will soon begin Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer.

Dramatic changes needed in farming practices to keep pace with climate change

Major changes in agricultural practices will be required to offset increases in nutrient losses due to climate change, according to research published by a Lancaster University-led team.

Seasonal Effects: "Winter foals" are smaller than foals born in summer

Seasonal and diurnal rhythms determine the life cycle of many animal species. In equids this is not only true for wild species such as the Przewalski but season-dependent metabolic changes also exist in domesticated horses. Horses can reduce their metabolic activity during the cold season and thus reduce heat loss. The effects of such seasonal changes on pregnancy and foetal development, however, have not been investigated so far. Researchers from Vetmeduni Vienna could now demonstrate that foals born in winter are smaller than herd mates born later in the year.

NASA Sees High Clouds Fill Typhoon Noru's Eye

NASA's Terra satellite passed over Typhoon Noru early on August 3 and saw that high clouds had moved over the eye.

Two Weeks in the Life of a Sunspot

On July 5, 2017, NASA’s Solar Dynamics Observatory watched an active region — an area of intense and complex magnetic fields — rotate into view on the Sun. The satellite continued to track the region as it grew and eventually rotated across the Sun and out of view on July 17. 

Wildlife royalties – a future for conservation?

Writing in the journal Animals, they muse on whether organisations that profit in some way from wildlife imagery and popularity, could establish a corporate responsibility to contribute a portion of this income to the conservation of the animals represented.

Temperatures Rising

The Paris Climate Agreement of 2016, which saw 195 nations come together in the shared goal of ameliorating climate change, set forth an ambitious goal of limiting global temperature rise to less than 2 degrees Celsius. Since then, many have wondered, is that even scientifically possible? Unfortunately, the odds aren’t looking good.