Genes and toxic chemicals

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Research is increasingly revealing how toxic chemicals disrupt gene activity and other cell processes in ways that lead to health problems

Research is increasingly revealing how toxic chemicals disrupt gene activity and other cell processes in ways that lead to health problems -- and why some individuals are particularly vulnerable. For example, studies suggest that genetic variations make some people more likely to experience side effects from certain medications, such as some cancer treatments and blood thinners.

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How can this type of research -- known as toxicogenomic research-- best be applied to protect public health, and that of individuals? APPLICATIONS OF TOXICOGENOMIC TECHNOLOGIES TO PREDICTIVE TOXICOLOGY AND RISK ASSESSMENT, a new report from the National Research Council, examines future applications and benefits of this research, and recommends ways government agencies and others can move the field forward. It also explores the ethical and social issues raised by toxicogenomic methods -- such as how to protect the privacy of individuals' genetic information.

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Reporters can obtain copies by contacting the National Academies' Office of News and Public Information at 202-334-2138 or e-mailing This email address is being protected from spambots. You need JavaScript enabled to view it.. Advance copies will be available to reporters only starting at noon EDT on Thursday, Oct. 4. THE REPORT IS EMBARGOED AND NOT FOR PUBLIC RELEASE BEFORE 10 A.M. EDT ON TUESDAY, OCT. 9.