Hip fracture risk seen with chronic kidney disease
NEW YORK (Reuters Health) - Men with chronic kidney disease are at increased risk of sustaining a hip fracture, researchers report.
The relationship between end-stage kidney disease and hip fracture has been well established, they note in the American Journal of Kidney Diseases, but the fracture risk in chronic kidney disease patients who do not require dialysis has not been as well studied.
Dr. Bryan Kestenbaum, of the University of Washington, Seattle, and colleagues studied 13,632 men with chronic renal disease and 19,459 without kidney disease who were treated at a VA Medical Center in the Northeast.
Over a period of about 3.5 years, 176 patients sustained a hip fracture.
After making adjustments for age, body mass index, and diabetes, Kestenbaum's group found that men with moderate chronic kidney disease were 28 percent more likely to break a hip than were men with normal kidneys.
Among men with very poor kidney function, the risk of hip fracture was nearly four times higher.
Given the large number of patients who have severe kidney disease, the investigators advise, more aggressive measures to control metabolic derangements "may be important to prevent this potentially devastating clinical outcome."
SOURCE: American Journal of Kidney Diseases, January 2008.