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: Gold Catalyst



From: Andy Soos, ENN
Published September 28, 2012 10:20 AM

Gold Catalyst

Gold is a precious metal and looks great in a ring. How about a benzene ring? Biaryls, compounds containing two directly connected benzene rings, frequently feature in pharmaceuticals and agrochemicals as well as forming the core of many functional materials (for example LEDs, liquid crystals, conducting polymers). A new way to prepare biaryls — compounds that are essential building blocks in the creation of drugs and many modern materials such as LEDs — using gold as a catalyst is described by researchers from the University of Bristol in this week's edition of Science. Gold catalysis is easier, cheaper and more environmentally friendly than current methods which use palladium as a catalyst.

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Gold has a bright yellow color and luster traditionally considered attractive, which it maintains without oxidizing in air or water. Chemically, gold is a transition metal and a group 11 element. It is one of the least reactive chemical elements solid under standard conditions.

Catalysts are metals that speed up chemical reactions, such as when the platinum in a car's catalytic converter instantly converts polluting engine exhaust to oxygen, nitrogen, carbon dioxide and water.

Gold had been overlooked by most researchers as a possible industrial catalyst until very recently. Examples of applications where a gold based catalyst is being used, developed or considered for use include the following:

Vinyl Acetate Monomer (VAM) Production

Methyl Glycolate Pilot Plant

Conversion of Glucose to Gluconic Acid

Over the last two decades, methods for preparing biaryls have relied predominantly on cross-coupling — a method in which two differentially pre-functionalised benzene rings are connected together in the presence of a catalyst, most often based on the precious metal palladium. The power of this method was recognised in the 2010 Nobel Prize in Chemistry.

However, concerns regarding the environmental impact of such processes, arising from use of toxic metals and the requirement for pre-functionalisation of the coupling partners, have led to a search for more benign alternatives.

As a consequence, much recent interest has focussed on replacing one of the pre-functionalised benzene rings with the desired benzene ring itself, a process known as direct coupling. Despite major advances in this area, most direct couplings still only operate under undesirable conditions, for example strongly acidic solvents, high temperatures, high concentrations of toxic metal catalysts, large excess of one reactant, and so on.

In their report to Science, Professor Guy Lloyd-Jones, Dr Chris Russell, and PhD student Liam Ball from the University of Bristol’s Chemical Synthesis Doctoral Training Centre, describe a new method for performing direct couplings.

The reaction employs a low concentration of a gold catalyst to couple a simple aromatic ring with a non-toxic silicon-based partner, to generate biaryls at room temperature and under exceptionally mild conditions.

These conditions then allow many of the structural features required in drug-like molecules to be tolerated; indeed, the group illustrated the applicability of their chemistry through the concise synthesis of diflunisal (Merck & Co.), a non-opiod, non-steroidal anti-inflammatory drug used for the treatment of chronic arthritis, and for the relief of acute pain following oral surgery.

For further information see Gold Catalyst.

Gold image via Wikipedia.

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