It is a painful lesson of our time that the things we depend on to make our lives more comfortable can also kill us. Our addiction to fossils fuels is the obvious example, as we come to terms with the slow-motion catastrophe of climate change. But we are addicted to nitrogen, too, in the fertilizers that feed us, and it now appears that the combination of climate change and nitrogen pollution is multiplying the possibilities for wrecking the world around us.
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In the brains of Alzheimer’s patients, many of the genes required to form new memories are shut down by a genetic blockade, contributing to the cognitive decline seen in those patients.
MIT researchers have now shown that they can reverse that memory loss in mice by interfering with the enzyme that forms the blockade. The enzyme, known as HDAC2, turns genes off by condensing them so tightly that they can’t be expressed.
For several years, scientists and pharmaceutical companies have been trying to develop drugs that block this enzyme, but most of these drugs also block other members of the HDAC family, which can lead to toxic side effects. The MIT team has now found a way to precisely target HDAC2, by blocking its interaction with a binding partner called Sp3.
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Researchers funded by the National Science Foundation (NSF) have publicly released high-resolution maps of Antarctica's McMurdo Dry Valleys, a globally unique polar desert.
The high-resolution maps cover 3,564 square kilometers of the McMurdo Dry Valleys and allow researchers to compare present-day conditions with lower-resolution LIDAR surveys conducted almost 13 years ago.
Scientists from Portland State University led the new research project, which mapped the area using more sophisticated LIDAR, a remote-sensing method that uses laser beam pulses to measure the distance from the detector to the Earth's surface.
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An abnormal season of intense glacial melt in 2002 triggered multiple distinct changes in the physical and biological characteristics of Antarctica's McMurdo Dry Valleys over the ensuing decade, new research funded by the National Science Foundation (NSF) shows.
The findings suggest that abrupt, short-lived climate events can cause long-term alterations in polar regions that unfold over the span of several years and subsequently change the overall trajectory of an ecosystem.
The new research appears today in the journal Nature Ecology and Evolution.
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If ocean temperatures continue to climb, you’re going to need a bigger boat.
Great white sharks could one day be swimming in British Columbia waters, according to William Cheung, associate professor at the Institute for the Oceans and Fisheries at UBC who studies the impact of climate change on marine ecosystems.
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