Female patients with locally advanced esophageal cancer that is treated with chemotherapy and radiation therapy before surgery are more likely to have a favorable response to the treatment than male patients are, and women are less likely to experience cancer recurrence, according to a study published online today in The Annals of Thoracic Surgery.

The recent discovery of E. coli carrying mcr-1 and ndm-5 — genes that make the bacterium immune to last-resort antibiotics — has left clinicians without an effective means of treatment for the superbug.

But in a new study, University at Buffalo researchers have assembled a team of three antibiotics that, together, are capable of eradicating the deadly bacterium. The groundbreaking research was recently published in mBio, a journal for the American Society of Microbiology.

Under a microscope, a cell’s cytoplasm can resemble a tiny underwater version of New York’s Times Square: Thousands of proteins swarm through a cytoplasm’s watery environment, coming together and breaking apart like a cytoskeletal flash mob.

Organelles such as mitochondria and lysosomes must traverse this crowded, ever-changing cytoplasmic space to deliver materials to various parts of a cell.

Now engineers at MIT have found that these organelles and other intracellular components may experience the surrounding cytoplasm as very different environments as they travel. For instance, a cell’s nucleus may “feel” the cytoplasm as a fluid, honey-like material, while mitochondria may experience it more like toothpaste.

It is now possible to scour complete human genomes for the presence of disease-associated genes without revealing any genetic information not directly associated with the inquiry, say Stanford University researchers.

This “genome cloaking” technique, devised by biologists, computer scientists and cryptographers at the university, ameliorates many concerns about genomic privacy and potential discrimination based on an individual’s genome sequence.

Researchers have identified, for the first time, the likely origin of the cross-reactivity between cypress pollen, peaches and citrus fruits.

When we have a new experience, the memory of that event is stored in a neural circuit that connects several parts of the hippocampus and other brain structures. Each cluster of neurons may store different aspects of the memory, such as the location where the event occurred or the emotions associated with it.

Neuroscientists who study memory have long believed that when we recall these memories, our brains turn on the same hippocampal circuit that was activated when the memory was originally formed. However, MIT neuroscientists have now shown, for the first time, that recalling a memory requires a “detour” circuit that branches off from the original memory circuit.

The expansion of wind and solar energy, and the resulting avoided emissions from fossil fuels, helped prevent up to 12,700 premature deaths in the U.S. from 2007 to 2015, according a new study in the journal Nature Energy.

The ancient Romans were famous for their advanced water supply. But the drinking water in the pipelines was probably poisoned on a scale that may have led to daily problems with vomiting, diarrhoea, and liver and kidney damage. This is the finding of analyses of water pipe from Pompeii.

- The concentrations were high and were definitely problematic for the ancient Romans. Their drinking water must have been decidedly hazardous to health.

Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, which chronically infects around half of all humans. However, unlike tumour viruses, bacteria do not deposit transforming genes in their host cells and how they are able to cause cancer has so far remained a mystery. An interdisciplinary research team at the Max Planck Institute in Berlin in collaboration with researchers in Stanford, California, has now discovered that the bacterium sends stem cell renewal in the stomach into overdrive – and stem cell turnover has been suspected by many scientists to play a role in the development of cancer. By showing that the stomach contains two different stem cell types, which respond differently to the same driver signal, they have uncovered a new mechanism of tissue plasticity. It allows tuning tissue renewal in response to bacterial infection.

In a new study, researchers report people who have experienced an aneurysm have another reason to quit smoking.