Changing the natural electrical signaling that exists in cells outside the nervous system can improve resistance to life-threatening bacterial infections, according to new research from Tufts University biologists.  The researchers found that administering drugs, including those already used in humans for other purposes, to make the cell interior more negatively charged strengthens tadpoles’ innate immune response to E. coli infection and injury. This reveals a novel aspect of the immune system – regulation by non-neural bioelectricity – and suggests a new approach for clinical applications in human medicine. The study is published online May 26, 2017, in npj Regenerative Medicine, a Nature Research journal.

“All cells, not just nerve cells, naturally generate and receive electrical signals. Being able to regulate such non-neural bioelectricity with the many ion channel and neurotransmitter drugs that are already human-approved gives us an amazing new toolkit to augment the immune system’s ability to resist infections,” said the paper’s corresponding author Michael Levin, Ph.D., Vannevar Bush professor of biology and director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology in the School of Arts and Sciences. Levin is also an associate faculty member of the Wyss Institute of Biologically Inspired Engineering at Harvard University.

Diesel pollution is linked with heart damage, according to research presented today at EuroCMR 2017 (1).

“There is strong evidence that particulate matter (PM) emitted mainly from diesel road vehicles is associated with increased risk of heart attack, heart failure, and death,” said lead author Dr Nay Aung, a cardiologist and Wellcome Trust research fellow, William Harvey Research Institute, Queen Mary University of London, UK. “This appears to be driven by an inflammatory response – inhalation of fine particulate matter (PM2.5) causes localised inflammation of the lungs followed by a more systemic inflammation affecting the whole body.”

Coronaviruses such as Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome (MERS) cause serious and often fatal disease in people, but bats seem unharmed.

Veterinary microbiology PhD candidate Arinjay Banerjee and his professor Vikram Misra have now found some clues.

Everything under the sun you need to know about protecting your skin.

With summer right ahead, you may be planning to relax poolside or at the beach. But enjoying summer's longer and sunnier days outdoors means your skin is vulnerable to sunburn. Unless you take the right precautions, sun exposure (even if you don't get scorched) can damage your skin, causing wrinkles, age spots and even skin cancer.

A University of Oklahoma Civil Engineering and Environmental Science Professor Robert Nairn and his co-authors have conducted a collaborative study that suggests exposure to trace metals from potatoes grown in soil irrigated with waters from the Potosi mining region in Bolivia, home to the world’s largest silver deposit, may put residents at risk of non-cancer health illnesses.

University of Texas Medical Branch at Galveston scientists have unlocked mysteries of how the Ebola virus hampers the body’s natural defenses to speed the rate of infection and its accompanying lethal disease, according to a new report in PLOS Pathogens. The study was conducted in collaboration with the University of Washington and The National Institute of Allergy and Infectious Diseases.

A new study has found that children, especially boys, whose mothers were exposed to higher levels of outdoor particulate air pollution at the same time that they were very stressed were most likely to develop asthma by age six. The study was presented at the 2017 American Thoracic Society International Conference. 

The team, led by senior investigator Rosalind Wright, MD, MPH, co-director of the Institute for Exposomics Research at the Icahn School of Medicine at Mount Sinai, conducted this study because of their overarching interest in understanding how these and other environmental factors interact to produce respiratory health disparities.

High levels of air pollution over time may get in the way of a good night’s sleep, according to new research presented at the ATS 2017 International Conference.

“Prior studies have shown that air pollution impacts heart health and affects breathing and lung function, but less is known about whether air pollution affects sleep,” said lead author Martha E. Billings, MD, MSc, assistant professor of medicine at the University of Washington. “We thought an effect was likely given that air pollution causes upper airway irritation, swelling and congestion, and may also affect the central nervous system and brain areas that control breathing patterns and sleep.”

A study from the Wellcome Trust Sanger Institute, the Wellcome Trust Centre for Human Genetics and their collaborators have identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40 per cent reduced risk from severe malaria.

A new study led by Colorado State University researchers found that Aedes aegypti, the primary mosquito that carries Zika virus, might also transmit chikungunya and dengue viruses with one bite. The findings shed new light on what’s known as a coinfection, which scientists said is not yet fully understood and may be fairly common in areas experiencing outbreaks.