Each year millions of animals are used in Canada for medical research and toxicity testing, but a growing body of scientific evidence points to the difficulties of treating humans like 70-kg mice.

After years of using rodents to conduct heart disease research, Charu Chandrasekera began to question the value of using animals as stand-ins for humans. She lost her fervour for animal research after her father suffered a heart attack, bringing home to her the realization that human relevance must be at the forefront of biomedical discoveries.

Researchers from the University of Oxford are using a unique blend of virtual reality and innovative genetic techniques to understand the causes of diseases such as diabetes and anaemia.

Corey Filiaggi is describing the busy and collegial environment at the Berman Zebrafish Laboratory, where she’s spent the past three years working towards a master’s degree in Pathology. And it’s true that, only hours after a midnight return from the North Atlantic Zebrafish Research Symposium in Maine, the motley mix of undergraduate and graduate students and lab technicians milling about give off the vibe of a very science-focused village.

Lung cancer screening is likely to be cost-effective, particularly if it also identifies other tobacco-related conditions in high-risk people, suggests new research published in the Journal of Thoracic Oncology (JTO).

Wherever you find people, you also find bacteria and other microorganisms. The International Space Station is no exception.

That generally is not a problem. For one thing, the space station is kept cleaner than many environments on Earth. Routine cleaning activities are included on astronaut task schedules. Cargo sent to the station, and the vehicles that carry it, undergo a rigorous cleaning process and monitoring for microorganisms before launch. Crew members assigned to the space station spend 10 days in pre-flight quarantine.

For another, scientists regularly monitor the interior of this and other spacecraft, a process that started with the Apollo missions.

Researchers from Case Western Reserve University School of Medicine in collaboration with researchers from Dartmouth Geisel School of Medicine and RWTH Aachen University (Germany) have adapted virus particles—that normally infect potatoes—to serve as cancer drug delivery devices for mice. But in a recent article published in Nano Letters, the team showed injecting the virus particles alongside chemotherapy drugs, instead of packing the drugs inside, may provide an even more potent benefit.

Sometimes, a little snot goes a long way. And not just in the physical, stretchy sense. Today, some decade-old snot collected from the sinuses of cancer patients revealed a new technique to forecast how flu evolves.

A new analysis shows that septic systems in the United States routinely discharge pharmaceuticals, consumer product chemicals, and other potentially hazardous chemicals into the environment. The study, published June 15 in the journal Environmental Science & Technology, is the most comprehensive assessment to date of septic systems as important sources of emerging contaminants, raising health concerns since many of these chemicals, once discharged, end up in groundwater and drinking water supplies.

Known as contaminants of emerging concern (CECs), these types of pollutants are frequently detected in U.S. rivers, lakes, and drinking water supplies. However, the U.S. Environmental Protection Agency does not currently regulate them in drinking water. Many emerging contaminants are hormone disruptors.

Researchers have more evidence that males and females are different, this time in the fluid that helps protect the cartilage in their knee joints.

They have found in the synovial fluid of this joint, clear differences in the messages cells are sending and receiving via tiny pieces of RNA, called microRNA, in males and females with the common and debilitating condition osteoarthritis.

A new analysis shows that individuals with high levels of genetic variation and elevated exposure to ozone in the environment are at an even higher risk for developing autism than would be expected by adding the two risk factors together. The study is the first to look at the combined effects of genome-wide genetic change and environmental risk factors for autism, and the first to identify an interaction between genes and environment that leads to an emergent increase in risk that would not be found by studying these factors independently. A paper describing the research appears online in the journal Autism Research.

“Autism, like most human diseases, is complex,” said Scott B. Selleck, professor of biochemistry and molecular biology at Penn State and one of the leaders of the research team. “There are probably hundreds, if not thousands, of genes involved and up until now -- with very few exceptions -- these have been studied independently of the environmental contributors to autism, which are real. Our team of researchers represents a merger of people with genetic expertise and environmental epidemiologists, allowing us for the first time to answer questions about how genetic and environmental risk factors for autism interact.”