Fasting-Mimicking Diet Holds Promise for Treating People with Inflammatory Bowel Disease

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What if a special diet could reduce inflammation and repair your gut?

What if a special diet could reduce inflammation and repair your gut?

USC researchers provided evidence that a low-calorie “fasting-mimicking” diet has the potential to do just that. Published in the Tuesday edition of Cell Reports, the study reports on the health benefits of periodic cycles of the diet for people with inflammation and indicated that the diet reversed inflammatory bowel disease (IBD) pathology in mice.

Results showed that fasting-mimicking diet caused a reduction in intestinal inflammation and an increase in intestinal stem cells in part by promoting the expansion of beneficial gut microbiota. Study authors say the reversal of IBD pathology in mice, together with its anti-inflammatory effects demonstrated in a human clinical trial, indicate that the regimen has the potential to mitigate IBD.

“This study for the first time combines two worlds of research,” said Valter Longo, a study author and the director of the USC Longevity Institute at the USC Leonard Davis School of Gerontology and professor of biological sciences at the USC Dornsife College of Letters, Arts and Sciences. “The first is about what you should eat every day, and many studies point to a diet rich in vegetables, nuts and olive oil. The second is fasting and its effects on inflammation, regeneration and aging.”

Read more at University of Southern California

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