Study Reveals How Too Much Fluoride Causes Defects in Tooth Enamel

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Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. 

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.

Fluoride is a naturally occurring mineral that helps to prevent cavities by promoting mineralization and making tooth enamel more resistant to acid. It is added to drinking water around the world—the U.S. Department of Health and Human Services recommends a level of 0.7 parts per million—and all toothpastes backed by the American Dental Association’s Seal of Acceptance contain fluoride. The Centers for Disease Control and Prevention (CDC) named water fluoridation one of 10 great public health achievements of the 20th century for its role in reducing tooth decay.

While low levels of fluoride help strengthen and protect tooth enamel, too much fluoride can cause dental fluorosis—a discoloration of teeth, usually with opaque white marks, lines, or mottled enamel and poor mineralization. Dental fluorosis occurs when children between birth and around nine years of age are exposed to high levels fluoride during this critical window when their teeth are forming, and can actually increase their risk of tooth decay. A survey by the CDC found that roughly 25 percent of the U.S. population examined (ages 6 to 49) show some degree of dental fluorosis.

Read more at New York University

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