Combined Short-Term Effects of Air Pollutants Linked to 146,500 Premature Deaths per Year in Europe

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Fine particles (PM₂.₅) were associated with around 79,000 preventable deaths, followed by nitrogen dioxide (NO₂), ozone (O₃) and coarser particles (PM₂.₅-₁₀, particles with a diameter between 2.5 and 10 micrometres).

Fine particles (PM₂.₅) were associated with around 79,000 preventable deaths, followed by nitrogen dioxide (NO₂), ozone (O₃) and coarser particles (PM₂.₅-₁₀, particles with a diameter between 2.5 and 10 micrometres). These are among the findings of a new study conducted by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the ”la Caixa” Foundation, in collaboration with the Barcelona Supercomputing Center–Centro Nacional de Supercomputación (BSC-CNS), which provides the first Europe-wide estimate of short-term mortality associated with the combined effects of multiple pollutants across 31 European countries. The findings, published in Nature Health, support the development of impact-based early warning systems to help protect the population from the health effects of air pollution.

Although the overall health burden is dominated by long-term exposure, short-term air pollution can trigger acute physiological responses, such as systemic inflammation, autonomic imbalance and increased blood clotting, that elevate mortality risk over the following days. Recent studies have shown that daily pollution levels are linked to daily short-term increases in mortality, but important limitations remain. Most research focuses only on cities, overlooking peri-urban and rural areas; and they often fail to account for regional differences in vulnerability (such as age, baseline health, socioeconomic status or environment) and air pollution toxicity. In addition, pollutants are usually analysed separately, making it difficult to understand their combined effects.

“Our study addressed these limitations by combining daily data on major air pollutants across Europe with the new mortality database from the EARLY-ADAPT project of the European Research Council (ERC), which covers the whole population in 31 countries representing over 530 million people,” explains Zhao-Yue Chen, researcher at ISGlobal and first author of the study. “This allows a more precise analysis of how short-term exposure to the major pollutants affects people differently depending on age, sex and cause of death.” The study analysed nearly 89 million deaths recorded between 2003 and 2019 across 653 European regions.

Read More: Barcelona Institute for Global Health

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