Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent painful swellings of the skin and mucous membranes. Without treatment, patients’ quality of life is noticeably compromised: Angioedema may not only be disfiguring; in the gastrointestinal tract it may lead to severe abdominal colic ad in the upper airways it can even be fatal if left untreated. The frequency of angioedema attacks is unpredictable and varies from patient to patient; swellings may occur up to several times a week. The disorder affects about one to two in a hundred thousand people. 

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The exact science of tree sap transport has puzzled plant physiologists for many years. Sap’s migration throughout tree trunks and branches is linked heavily to transpiration, the movement and subsequent evaporation of moisture from plants. As carbon dioxide diffuses inward from the air to plant leaves, a vapor pressure deficit between the leaf interior and surrounding atmosphere causes evaporation. This generates tension within leaf cell walls that is then transmitted via sap to tracheids — conductive hollow wood cells with vertical grooves that comprise the trunk, stem, and branches of trees and are collectively called sapwood. The resulting negative sap pressure draws water from roots to leaves, sometimes to heights of over 300 feet. 

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Ullas Karanth, a senior scientist with the Wildlife Conservation Society, is one of the world’s premier tiger experts and a leader in the effort to restore India’s depleted tiger populations. Raised in the South India state of Karnataka, he has spent much of his professional life studying and working to bring back tigers there, starting in Nagarahole National Park in the foothills of the Western Ghats, and then across a 10,000-square-mile region of that mountain range.

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