A naturally occurring hormone that plays an important role in fetal development may be the basis for a new type of reversible contraceptive that can protect ovaries from the damage caused by chemotherapy drugs. In their report receiving online publication in PNAS, a team from the Pediatric Surgical Research Laboratories in the Massachusetts General Hospital (MGH) Department of Surgery describes using Mullerian Inhibiting Substance (MIS) to halt, in a mouse model, the early development of the ovarian follicles in which oocytes mature, an accomplishment that protects these primordial follicles from chemotherapy-induced damage. 

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Oceanographers commonly calculate large scale surface ocean circulation from satellite sea level information using a concept called “geostrophy,” which describes the relationship between oceanic surface flows and sea level gradient. Conversely, researchers rely on data from in-water current meters to measure smaller scale motion. New research led by University of HawaiÊ»i at Mānoa oceanographer Bo Qiu has determined from observational data the length scale at which using sea level height no longer offers a reliable calculation of circulation.

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Last year will go down in history as the year when the planet’s atmosphere broke a startling record: 400 parts per million of carbon dioxide. The last time the planet’s air was so rich in CO2 was millions of years ago, back before early predecessors to humans were likely wielding stone tools; the world was a few degrees hotter back then, and melted ice put sea levels tens of meters higher.

“We’re in a new era,” says Ralph Keeling, director of the Scripps Institution of Oceanography’s CO2 Program in San Diego. “And it’s going fast. We’re going to touch up against 410 pretty soon.”

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